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Published: Friday, 17 June 2016 17:05

Murphy & Wülfing receive grants from new international collaboration program

MMBioS investigators Bob Murphy (Carnegie Mellon University) and Christoph Wülfing (University of Bristol) have just received grants from a new program encouraging collaboration between U.S. and U.K. investigators. The program, run jointly by the U.S. National Science Foundation (NSF) and the U.K. Biotechnology and Biological Sciences Research Council, allows the investigators to submit a single proposal that is reviewed by only one of the agencies: if it scores highly, the second agency simply accepts the recommendation of the first. The project builds on initial work funded by NSF and subsequent work done through MMBioS that led to a recent major paper in Science Signaling. The project will involve analyzing fluorescence microscope movies to create spatiotemporal maps of proteins involved in signaling by T cells, a key component of the immune system. The maps will be combined with data on cell-wide protein phosphorylation and used both to infer potential signaling complexes, and to estimate the apparent affinities and potential causal relationships amongst proteins involved in T lymphocyte signaling.